SNCA, MAPT, and GSK3B in Parkinson disease: a gene–gene interaction study
Identifieur interne : 000161 ( Main/Exploration ); précédent : 000160; suivant : 000162SNCA, MAPT, and GSK3B in Parkinson disease: a gene–gene interaction study
Auteurs : C. Wider [États-Unis, Suisse] ; C. Vilari O-Güell [États-Unis] ; M. G. Heckman [États-Unis] ; B. Jasinska-Myga [États-Unis, Pologne] ; A. I. Ortolaza-Soto [États-Unis] ; N. N. Diehl [États-Unis] ; J. E. Crook [États-Unis] ; S. A. Cobb [États-Unis] ; J. A. Bacon [États-Unis] ; J. O. Aasly [Norvège] ; J. M. Gibson [Irlande (pays)] ; T. Lynch [Irlande (pays)] ; R. J. Uitti [États-Unis] ; Z. K. Wszolek [États-Unis] ; M. J. Farrer [États-Unis] ; O. A. Ross [États-Unis]Source :
- European Journal of Neurology [ 1351-5101 ] ; 2011-06.
English descriptors
- KwdEn :
Abstract
Background and purpose: Recent evidence suggests that variation in the SNCA, MAPT, and GSK3B genes interacts in affecting risk for Parkinson disease (PD). In the current study, we attempt to validate previously published findings, evaluating gene–gene interactions between SNCA, MAPT, and GSK3B in association with PD. Methods: Three Caucasian PD patient–control series from the United States, Ireland, and Norway (combined n = 1020 patients and 1095 controls) were genotyped for SNCA rs356219, MAPT H1/H2‐discriminating SNP rs1052553, and GSK3B rs334558 and rs6438552. Results: Our findings indicate that as previously reported, the SNCA rs356219‐G allele and MAPT rs1052553 (H1 haplotype) were both associated with an increased risk of PD, whilst contrary to previous reports, GSK3B variants were not. No pair‐wise interaction was observed between SNCA, MAPT, and GSK3B; the risk effects of SNCA rs356219‐G and MAPT rs1052553‐H1 were seen in a similar manner across genotypes of other variants, with no evidence suggesting synergistic, antagonistic, or deferential effects. Conclusions: In the Caucasian patient–control series examined, risk for PD was influenced by variation in SNCA and MAPT but not GSK3B. Additionally, those three genes did not interact in determining disease risk.
Url:
DOI: 10.1111/j.1468-1331.2010.03297.x
Affiliations:
- Irlande (pays), Norvège, Pologne, Suisse, États-Unis
- Canton de Vaud, Floride, Trøndelag
- Lausanne, Trondheim
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">SNCA, MAPT, and GSK3B in Parkinson disease: a gene–gene interaction study</title><author><name sortKey="Wider, C" sort="Wider, C" uniqKey="Wider C" first="C." last="Wider">C. Wider</name></author><author><name sortKey="Vilari O Ell, C" sort="Vilari O Ell, C" uniqKey="Vilari O Ell C" first="C." last="Vilari O-Güell">C. Vilari O-Güell</name></author><author><name sortKey="Heckman, M G" sort="Heckman, M G" uniqKey="Heckman M" first="M. G." last="Heckman">M. G. Heckman</name></author><author><name sortKey="Jasinska Yga, B" sort="Jasinska Yga, B" uniqKey="Jasinska Yga B" first="B." last="Jasinska-Myga">B. Jasinska-Myga</name></author><author><name sortKey="Ortolaza Oto, A I" sort="Ortolaza Oto, A I" uniqKey="Ortolaza Oto A" first="A. I." last="Ortolaza-Soto">A. I. Ortolaza-Soto</name></author><author><name sortKey="Diehl, N N" sort="Diehl, N N" uniqKey="Diehl N" first="N. N." last="Diehl">N. N. Diehl</name></author><author><name sortKey="Crook, J E" sort="Crook, J E" uniqKey="Crook J" first="J. E." last="Crook">J. E. Crook</name></author><author><name sortKey="Cobb, S A" sort="Cobb, S A" uniqKey="Cobb S" first="S. A." last="Cobb">S. A. Cobb</name></author><author><name sortKey="Bacon, J A" sort="Bacon, J A" uniqKey="Bacon J" first="J. A." last="Bacon">J. A. Bacon</name></author><author><name sortKey="Aasly, J O" sort="Aasly, J O" uniqKey="Aasly J" first="J. O." last="Aasly">J. O. Aasly</name></author><author><name sortKey="Gibson, J M" sort="Gibson, J M" uniqKey="Gibson J" first="J. M." last="Gibson">J. M. Gibson</name></author><author><name sortKey="Lynch, T" sort="Lynch, T" uniqKey="Lynch T" first="T." last="Lynch">T. Lynch</name></author><author><name sortKey="Uitti, R J" sort="Uitti, R J" uniqKey="Uitti R" first="R. J." last="Uitti">R. J. Uitti</name></author><author><name sortKey="Wszolek, Z K" sort="Wszolek, Z K" uniqKey="Wszolek Z" first="Z. K." last="Wszolek">Z. K. Wszolek</name></author><author><name sortKey="Farrer, M J" sort="Farrer, M J" uniqKey="Farrer M" first="M. J." last="Farrer">M. J. Farrer</name></author><author><name sortKey="Ross, O A" sort="Ross, O A" uniqKey="Ross O" first="O. A." last="Ross">O. A. Ross</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A57633AA3A8126E755E495E6F81A87D2F72ABC6C</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1111/j.1468-1331.2010.03297.x</idno><idno type="url">https://api.istex.fr/document/A57633AA3A8126E755E495E6F81A87D2F72ABC6C/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000732</idno><idno type="wicri:Area/Main/Curation">000640</idno><idno type="wicri:Area/Main/Exploration">000161</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">SNCA, MAPT, and GSK3B in Parkinson disease: a gene–gene interaction study</title><author><name sortKey="Wider, C" sort="Wider, C" uniqKey="Wider C" first="C." last="Wider">C. Wider</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Vilari O Ell, C" sort="Vilari O Ell, C" uniqKey="Vilari O Ell C" first="C." last="Vilari O-Güell">C. Vilari O-Güell</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Heckman, M G" sort="Heckman, M G" uniqKey="Heckman M" first="M. G." last="Heckman">M. G. Heckman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biostatistics Unit, Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Jasinska Yga, B" sort="Jasinska Yga, B" uniqKey="Jasinska Yga B" first="B." last="Jasinska-Myga">B. Jasinska-Myga</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea><wicri:noRegion>Katowice</wicri:noRegion></affiliation></author><author><name sortKey="Ortolaza Oto, A I" sort="Ortolaza Oto, A I" uniqKey="Ortolaza Oto A" first="A. I." last="Ortolaza-Soto">A. I. Ortolaza-Soto</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Diehl, N N" sort="Diehl, N N" uniqKey="Diehl N" first="N. N." last="Diehl">N. N. Diehl</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biostatistics Unit, Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Crook, J E" sort="Crook, J E" uniqKey="Crook J" first="J. E." last="Crook">J. E. Crook</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biostatistics Unit, Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Cobb, S A" sort="Cobb, S A" uniqKey="Cobb S" first="S. A." last="Cobb">S. A. Cobb</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Bacon, J A" sort="Bacon, J A" uniqKey="Bacon J" first="J. A." last="Bacon">J. A. Bacon</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Aasly, J O" sort="Aasly, J O" uniqKey="Aasly J" first="J. O." last="Aasly">J. O. Aasly</name><affiliation wicri:level="3"><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim</wicri:regionArea><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Gibson, J M" sort="Gibson, J M" uniqKey="Gibson J" first="J. M." last="Gibson">J. M. Gibson</name><affiliation wicri:level="1"><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Neurology, Royal Victoria Hospital, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Lynch, T" sort="Lynch, T" uniqKey="Lynch T" first="T." last="Lynch">T. Lynch</name><affiliation wicri:level="1"><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Dublin Neurological Institute at the Mater Misericordiae Hospital and University College Dublin Conway Neuroscience Investigator, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Uitti, R J" sort="Uitti, R J" uniqKey="Uitti R" first="R. J." last="Uitti">R. J. Uitti</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Wszolek, Z K" sort="Wszolek, Z K" uniqKey="Wszolek Z" first="Z. K." last="Wszolek">Z. K. Wszolek</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Farrer, M J" sort="Farrer, M J" uniqKey="Farrer M" first="M. J." last="Farrer">M. J. Farrer</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Ross, O A" sort="Ross, O A" uniqKey="Ross O" first="O. A." last="Ross">O. A. Ross</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neurology</title><idno type="ISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2011-06">2011-06</date><biblScope unit="volume">18</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="876">876</biblScope><biblScope unit="page" to="881">881</biblScope></imprint><idno type="ISSN">1351-5101</idno></series><idno type="istex">A57633AA3A8126E755E495E6F81A87D2F72ABC6C</idno><idno type="DOI">10.1111/j.1468-1331.2010.03297.x</idno><idno type="ArticleID">ENE3297</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-5101</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>GSK3B</term><term>MAPT</term><term>Parkinson disease</term><term>SNCA</term><term>genetics</term><term>gene–gene interaction</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background and purpose: Recent evidence suggests that variation in the SNCA, MAPT, and GSK3B genes interacts in affecting risk for Parkinson disease (PD). In the current study, we attempt to validate previously published findings, evaluating gene–gene interactions between SNCA, MAPT, and GSK3B in association with PD. Methods: Three Caucasian PD patient–control series from the United States, Ireland, and Norway (combined n = 1020 patients and 1095 controls) were genotyped for SNCA rs356219, MAPT H1/H2‐discriminating SNP rs1052553, and GSK3B rs334558 and rs6438552. Results: Our findings indicate that as previously reported, the SNCA rs356219‐G allele and MAPT rs1052553 (H1 haplotype) were both associated with an increased risk of PD, whilst contrary to previous reports, GSK3B variants were not. No pair‐wise interaction was observed between SNCA, MAPT, and GSK3B; the risk effects of SNCA rs356219‐G and MAPT rs1052553‐H1 were seen in a similar manner across genotypes of other variants, with no evidence suggesting synergistic, antagonistic, or deferential effects. Conclusions: In the Caucasian patient–control series examined, risk for PD was influenced by variation in SNCA and MAPT but not GSK3B. Additionally, those three genes did not interact in determining disease risk.</div></front></TEI><affiliations><list><country><li>Irlande (pays)</li><li>Norvège</li><li>Pologne</li><li>Suisse</li><li>États-Unis</li></country><region><li>Canton de Vaud</li><li>Floride</li><li>Trøndelag</li></region><settlement><li>Lausanne</li><li>Trondheim</li></settlement></list><tree><country name="États-Unis"><region name="Floride"><name sortKey="Wider, C" sort="Wider, C" uniqKey="Wider C" first="C." last="Wider">C. Wider</name></region><name sortKey="Bacon, J A" sort="Bacon, J A" uniqKey="Bacon J" first="J. A." last="Bacon">J. A. Bacon</name><name sortKey="Cobb, S A" sort="Cobb, S A" uniqKey="Cobb S" first="S. A." last="Cobb">S. A. Cobb</name><name sortKey="Crook, J E" sort="Crook, J E" uniqKey="Crook J" first="J. E." last="Crook">J. E. Crook</name><name sortKey="Diehl, N N" sort="Diehl, N N" uniqKey="Diehl N" first="N. N." last="Diehl">N. N. Diehl</name><name sortKey="Farrer, M J" sort="Farrer, M J" uniqKey="Farrer M" first="M. J." last="Farrer">M. J. Farrer</name><name sortKey="Heckman, M G" sort="Heckman, M G" uniqKey="Heckman M" first="M. G." last="Heckman">M. G. Heckman</name><name sortKey="Jasinska Yga, B" sort="Jasinska Yga, B" uniqKey="Jasinska Yga B" first="B." last="Jasinska-Myga">B. Jasinska-Myga</name><name sortKey="Ortolaza Oto, A I" sort="Ortolaza Oto, A I" uniqKey="Ortolaza Oto A" first="A. I." last="Ortolaza-Soto">A. I. Ortolaza-Soto</name><name sortKey="Ross, O A" sort="Ross, O A" uniqKey="Ross O" first="O. A." last="Ross">O. A. Ross</name><name sortKey="Uitti, R J" sort="Uitti, R J" uniqKey="Uitti R" first="R. J." last="Uitti">R. J. Uitti</name><name sortKey="Vilari O Ell, C" sort="Vilari O Ell, C" uniqKey="Vilari O Ell C" first="C." last="Vilari O-Güell">C. Vilari O-Güell</name><name sortKey="Wszolek, Z K" sort="Wszolek, Z K" uniqKey="Wszolek Z" first="Z. K." last="Wszolek">Z. K. Wszolek</name></country><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Wider, C" sort="Wider, C" uniqKey="Wider C" first="C." last="Wider">C. Wider</name></region></country><country name="Pologne"><noRegion><name sortKey="Jasinska Yga, B" sort="Jasinska Yga, B" uniqKey="Jasinska Yga B" first="B." last="Jasinska-Myga">B. Jasinska-Myga</name></noRegion></country><country name="Norvège"><region name="Trøndelag"><name sortKey="Aasly, J O" sort="Aasly, J O" uniqKey="Aasly J" first="J. O." last="Aasly">J. O. Aasly</name></region></country><country name="Irlande (pays)"><noRegion><name sortKey="Gibson, J M" sort="Gibson, J M" uniqKey="Gibson J" first="J. M." last="Gibson">J. M. Gibson</name></noRegion><name sortKey="Lynch, T" sort="Lynch, T" uniqKey="Lynch T" first="T." last="Lynch">T. Lynch</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000161 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000161 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:A57633AA3A8126E755E495E6F81A87D2F72ABC6C
|texte= SNCA, MAPT, and GSK3B in Parkinson disease: a gene–gene interaction study
}}
| This area was generated with Dilib version V0.6.23. |  |